possible beneficial effects of lithium chloride on cerulein-induced acute pancreatitis in mice

Possible beneficial effects of lithium chloride on cerulein-induced acute pancreatitis in mice

One of the most important and serious disorders of gastrointestinal tract is acute pancreatitis which in severe form is associated with high mortality rate particularly in the presence of systemic inflammatory response and multiple organ failure. Apoptosis linked to oxidative stress has been shown in the pancreas of the patients with acute pancreatitis. Lithium, one of the most effective drugs ...

effect of lithium chloride on cerulein-induced acute pancreatitis in mice

Protective effect of Tribulus terrestris fruit extract on cerulein-induced acute pancreatitis in mice

Objective: Antioxidant, anti-inflammatory, analgesic and antimicrobial activities of Tribulus terrestris (T. terrestris) could be helpful in the treatment of acute pancreatitis; thus, this study was designed to investigate the effects of T. terrestris on cerulein-induced acute pancreatitis in mice. Materials and Methods: Three doses (100, 200 and 400 mg/kg) of T. terrestris hydro-alcoholic extr...

Beneficial effects of alpha lipoic acid on cerulein-induced experimental acute pancreatitis in rats.

BACKGROUND The present study aimed to determine the effects of alpha lipoic acid (ALA) on blood and tissue biochemical parameters, as well as tissue histopathology, in an experimental rat model of cerulein-induced acute pancreatitis (AP). METHODS Three groups consisting of eight rats each were used, as follows: Group 1, controls; Group 2, cerulein-induced pancreatitis group treated with salin...

Possible involvement of endogenous 5-HT in aggravation of cerulein-induced acute pancreatitis in mice.

The aim of the present study was to elucidate the pathogenic role of endogenous 5-HT in pancreatitis. Injections of cerulein at hourly intervals caused edematous pancreatitis in mice characterized by hyperenzymemia and histological alterations. While the cerulein-induced hyperenzymemia was attenuated in mice pretreated with p-CPA, a 5-HT depletor, it was exaggerated by the preferential 5-HT2A a...

preventive effect of cichorium intybus l. two extracts on cerulein-induced acute pancreatitis in mice

objectives: acute pancreatitis is an inflammatory condition of pancreas with sudden onset, high mortality rate and multiple organ failure characteristics. it has been shown that oxygen free radicals have an important role in development of pancreatitis and its complications. antioxidant, anti-inflammatory, anti-hepatotoxicity and gastroprotective properties of cichorium intybus l. suggest that ...